Table 5: Results of clinical trials assessing the efficacy of antimicrobial therapy for acute bacterial sinusitis in adults
Trial	Drug regimen	% of patients with clinical cure or improvement		% of patients with proven bacteriologic cure*
		Cure	Improvement
Williams et al [50]	TMP­SMX 1 tablet (double strength) bid × 3 d × 10 d	31 19	46 57	ND ND
Mattucci et al [69]	Amoxicillin 250 mg tid	50	45	95
	Minocycline 100 mg bid	40	60	100
Nielsen [70]	Amoxicillin­clavulanate 500/125 mg tid	96	96	96
	Loracarbef 400 mg bid	92	92	88
Casiano [71]	Amoxicillin 500 mg tid	73	27	100
	Azithromycin 500 m g × 1 d, 250 mg × 5 d	74	26	100
Dubois et al [73]	Amoxicillin­clavulanate 500/125 mg tid	67	26	90
	Clarithromycin 500 mg bid	64	33	87
Camacho et al [75]	Amoxicillin­clavulanate 500/125 mg tid	67	18	84
	Cefuroxime axetil 250 mg bid	63	19	87
Edelstein et al [77]	Amoxicillin 500 mg tid	47	49	ND
	Cefixime 400 mg × 10 d	51	43	ND
Gehanno et al [78]	Cefixime 400 mg × 10 d	82	2.7	84
Sydnor et al [79]	Cefuroxime axetil 250 mg bid	—	—	95**
	Cefaclor 500 mg tid	—	—	71**
Muller [80]	Azithromycin 500 mg × 3 d	66	27	92
	Clarithromycin 250 mg × 10 d	68	27	93
*ND = no data. **p < 0.05.

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